Billionaire biohacker Bryan Johnson, known for his $2 million-a-year anti-aging project Project Blueprint, recently turned heads with a tweet that combined health advice with a touch of intrigue. Johnson warned fitness enthusiasts against rinsing with antiseptic mouthwash immediately after exercising, citing research showing it can interfere with the blood-pressure-lowering benefits of a workout.
“Don’t mouthwash after a workout,” he tweeted. “Antibacterial mouthwash cut over 60% of exercise’s blood-pressure-lowering effect after 1 hour. And fully canceled it 2 hours post-exercise.” The research he referenced, titled Post-exercise hypotension and skeletal muscle oxygenation is regulated by nitrate-reducing activity of oral bacteria, explains the science behind the caution.
The Science Behind the Strange Advice
According to the study, oral bacteria play a crucial role in converting nitrates from food into nitric oxide, a molecule that helps blood vessels relax and lowers blood pressure. Using antiseptic mouthwash immediately after exercise kills these bacteria, reducing the cardiovascular benefits of physical activity. In short, your post-workout rinse could be wiping out part of your hard-earned gains.
More Than Just Fitness
This is not the first time Johnson has shared unconventional health insights. In the past, he has detailed how he meets his daily protein requirements entirely through plant-based sources, consuming 130 grams from flax, pea, hemp, legumes, vegetables, collagen peptides, nuts, and seeds. His rigorous anti-aging routine also includes hyperbaric oxygen therapy, red light exposure, sleep tracking, and intense workouts.
Health, Longevity, and Ethics
Johnson’s philosophy extends beyond personal health. He connects his diet and lifestyle choices to a broader vision he calls the “Four Layers of Don’t Die,” which intertwines individual vitality, cultural preservation, governance, and alignment with artificial intelligence. “Superintelligence is in the birth canal on planet Earth,” he wrote recently. “If control is limited, the only rational act is alignment. We align with life itself.”
Johnson’s mouthwash warning is a reminder that even small habits can have unexpected effects on health. Fitness enthusiasts aiming to maximize their workouts may want to rethink post-exercise routines—skipping the antiseptic rinse might just be the easiest tweak for better blood pressure and long-term cardiovascular benefits.
“Don’t mouthwash after a workout,” he tweeted. “Antibacterial mouthwash cut over 60% of exercise’s blood-pressure-lowering effect after 1 hour. And fully canceled it 2 hours post-exercise.” The research he referenced, titled Post-exercise hypotension and skeletal muscle oxygenation is regulated by nitrate-reducing activity of oral bacteria, explains the science behind the caution.
The Science Behind the Strange Advice
According to the study, oral bacteria play a crucial role in converting nitrates from food into nitric oxide, a molecule that helps blood vessels relax and lowers blood pressure. Using antiseptic mouthwash immediately after exercise kills these bacteria, reducing the cardiovascular benefits of physical activity. In short, your post-workout rinse could be wiping out part of your hard-earned gains.
Don’t mouthwash after a workout.
— Bryan Johnson (@bryan_johnson) October 10, 2025
Rinsing with antiseptic mouthwash after exercise can blunt the benefits of a workout.
Antibacterial mouthwash cut over 60% of exercise’s blood-pressure-lowering effect after 1 hour. And fully canceled it 2 hours post-exercise. pic.twitter.com/MCiEhRi3Ln
More Than Just Fitness
This is not the first time Johnson has shared unconventional health insights. In the past, he has detailed how he meets his daily protein requirements entirely through plant-based sources, consuming 130 grams from flax, pea, hemp, legumes, vegetables, collagen peptides, nuts, and seeds. His rigorous anti-aging routine also includes hyperbaric oxygen therapy, red light exposure, sleep tracking, and intense workouts.
Health, Longevity, and Ethics
Johnson’s philosophy extends beyond personal health. He connects his diet and lifestyle choices to a broader vision he calls the “Four Layers of Don’t Die,” which intertwines individual vitality, cultural preservation, governance, and alignment with artificial intelligence. “Superintelligence is in the birth canal on planet Earth,” he wrote recently. “If control is limited, the only rational act is alignment. We align with life itself.”
Johnson’s mouthwash warning is a reminder that even small habits can have unexpected effects on health. Fitness enthusiasts aiming to maximize their workouts may want to rethink post-exercise routines—skipping the antiseptic rinse might just be the easiest tweak for better blood pressure and long-term cardiovascular benefits.
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